吴秦洁，四川大学生物治疗全国重点实验室，研究员，博士生导师。四川省学术和技术带头人后备人选，四川大学青年骨干教师，教育部学位与研究生教育中心评估监测专家，国家及多个省部级科技专家库成员。自2014年工作以来，主持国家及省部级项目多项，以通讯作者和共同通讯作者发表高水平国际论文30余篇（其中IF>10 的20余篇），参编英文图书一本，获中国授权发明专利10项，其中转化1项。
本人长期专注肿瘤生物治疗领域，针对目前临床缺乏高效、低毒载药系统导致的肿瘤治疗欠佳现状，根据不同递送对象（DNA/SiRNA/化药/蛋白）特点，结合临床需求，设计构建系列高效、安全载体，以实现精准、有效、持久的抗肿瘤效果。
主要包括：
1. 研发人工仿病毒靶向基因递送系统，突破了超大质粒体内低转染、难编辑和易脱靶的瓶颈问题，实现了治疗性生物活性蛋白自供给，为基于生物活性蛋白的肿瘤治疗提供了新思路；
2. 发展按需释药的自组装载药体系，为打破耐药型肿瘤治疗提供了新选择；
3. 构建了肿瘤 pH 响应型自催化纳米反应器用于协同肿瘤光动力治疗，为氧底物依赖型的抗肿瘤治疗方式提供新方法。
未来，将持续保持“依据临床需求，打造高效、安全递送系统”为己任的热情，培养拥有科研思维，临床实践和国际视野的高端复合型医学人才，欢迎志同道合的朋友交流和报考。
国家重点实验室固定研究人员；中国生物医学工程学会会员；中国抗癌协会会员；教育部学位与研究生教育中心评估监测专家；国家及省部级科技项目评审专家,担任Biomaterials、Chem Eng J 、Cell Reports Medicine、Journal of Controlled Release、Materials Today Bio、Acta Biomaterialia、International Journal of Pharmaceutics等 20 余种国际学术期刊特邀审稿人。
【近期代表论文】
1. Ning Wang#, Chao Liu#, Yingjie Li, Dongxue Huang, Xinyue Wu,Xiaorong Kou,Xiye Wang, Qinjie Wu*, Changyang Gong*. A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis. Nature Communications, 2023, 14:779
2. Yan Wang#, Xianzhou Huang#, Shunyao Zhu, Lu Li, Jin Yang, Jie Li, Li Wang, Shuang Ma, Meiling Shen, Qinjie Wu*, Changyang Gong. A Quad-Functional On-demand Released Nanomissile Achieves Cascade Amplification therapy of Triple-Negative Breast Cancer Through Reversing Multiple Resistance. Chemical Engineering Journal, 2023,461:141816
3. Rui Luo#, Xinchao Li#, Miaomiao Zhang, Dongxue Huang, Hao Le, Tao He, Xiye Wang, Xiaorong Kou, Xinyue Wu, Qinjie Wu*, Changyang Gong*. An Asynchronous-Regulated Nanosheet Cascade Amplify Sonodynamic-Triggered Self-enhanced DNA Damage for Intensive Tumor Immunotherapy. ACS Nano, 2025, 19(27): 25552-25565.
4. Furong Liu#,Tao He#,Songlin Gong,Meiling Shen,Shuang Ma,Xianzhou Huang,Lu Li, Li Wang,Qinjie Wu*,Changyang Gong. A tumor pH-responsive autocatalytic nanoreactor as a H2O2 and O2 self-supplying depot for enhanced ROS-based chemo/photodynamic therapy. Acta Biomaterialia, 2022, 154: 510-522.
5. Li Wang#, Chao Liu#, Xinxin Wang, Shuang Ma, Furong Liu, Yi Zhang, Yan Wang, Meiling Shen, Xinyue Wu, Qinjie Wu*, Changyang Gong*. Tumor-Specific Activated Nano-Domino-CRISPR to Amplify Intrinsic Oxidative and Activate Endogenous Apoptosis for Spatiotemporally Specific Therapy. Biomaterials,2023,295：122056
6. Linjiang Song, Jin Yang, Zeyi Qin, Chunqing Ou, Rui Luo, Wen Yang, Li Wang, Ning Wang, Shuang Ma, Qinjie Wu*, Changyang Gong*. Multi-Targeted and On-Demand Non-Coding RNA Regulation Nanoplatform against Metastasis and Recurrence of Triple-Negative Breast Cancer. Small, 2023,19(23):2207576.
7. Liping Bai#, Jin Yang# Siting Yu, Zhongzheng Xiang, Yuanyuan Zeng, Meiling Shen, Xiaorong Kou, Qinjie Wu*, Changyang Gong*. Self-sufficient nanoparticles with dual-enzyme activity trigger radical storms and activate cascade-amplified antitumor immunologic responses. Acta Pharmaceutica Sinica B, 2024, 14(2): 821-835.
8. Wangxian Fu#, Xinchao Li#, Yingjie Li, Rui Luo, Chunqing Ou, Dongxue Huang, Xiuqi Liang, Yanjie You, Qinjie Wu*, Changyang Gong*. A programmable releasing versatile hydrogel platform boosts systemic immune responses via sculpting tumor immunogenicity and reversing tolerogenic dendritic cells. Biomaterials, 2024, 305, 122444.
9. Xinchao Li#, Xiuqi Liang#, Wangxian Fu, Rui Luo, Miaomiao Zhang, Xiaorong Kou, Yi Zhang, Yingjie Li, Dongxue Huang, Yanjie You, Qinjie Wu*, Changyang Gong*. Reversing cancer immunoediting phases with a tumor-activated and optically reinforced immunoscaffold. Bioactive Materials, 2024, 35, 228-241.
10. Haijun Li#, Xianzhou Huang#, Jin Yang#, Liping Bai, Meiling Shen, Yaqin Zhao, Changyang Gong, Yanjie You*, Qinjie Wu*. Limitation-circumventing and strength-capitalizing hydrogel potentiates durable antitumor immunity and robust abscopal effect in radiotherapy. Theranostics, 2026, 16(3): 1432-1444.
11. Xiaorong Kou#, Xue Wu#, Tao He, Liping Bai, Xinchao Li, Rui Luo, Yangsong Xu, Yixi Wang, Meiling Shen, Changyang Gong*, Qinjie Wu*. Tumor-activated dual metabolic nanomodulator turns over tolerogenic tumor control and unleashes systemic immune responses. Journal of Nanobiotechnology, 2026, 24: 206.
【参编图书】
Suleixin Yang, Qinjie Wu, Yuquan Wei, Changyang Gong. CRISPR-Cas9 Delivery by Artificial Virus (RRPHC). Chapter 5 in ‘CRISPR Gene Editing. Methods in Molecular Biology, vol 1961’. Editors: Yonglun Luo. Humana Press, New York, NY, USA. 2019, 81-91. (ISBN: 978-1-4939-9169-3, DOI: https://doi.org/10.1007/978-1-4939-9170-9_6)
【近期在研项目】
1. 基于二元重编程的归一化肿瘤疫苗在局部晚期三阴乳腺癌新辅助治疗中的作用与机制研究,国家自然科学基金面上项目,负责人
2. 巨噬细胞精准重编程CRISPR/Cas9系统原位构建抗原呈递细胞样巨噬细胞治疗肝细胞癌的研究,国家自然科学基金面上项目,负责人
3. 光控CRISPR/Cas9基因递送关键技术及其精准调控铁死亡在肺癌免疫治疗中的作用研究,四川省科技计划项目（重点研发项目）,负责人
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