中国康复医学会骨伤康复专委会脊柱疼痛学组委员、中国老年学和老年医学学会骨质疏松分会骨内科学组委员、四川省医学会骨科专委会青年委员会委员、四川省国际医学交流促进会骨与软组织肿瘤专业委员会委员、四川省医学传播学会脊柱外科分会委员、四川省医疗卫生与健康促进会脊柱外科学专委会委员、《中国修复重建外科杂志》青年编委。

目前主持国家自然科学基金面上及青年项目2项、四川省科技厅重点研发项目1项、四川省科技厅自然科学基金青年项目1项、中国博士后面上项目1项，四川大学博士后基金及其他校内/院内项目多项，累计科研经费190万元。授权发明专利4项，实用新型专利6项，转化2项。获得西藏自治区科学技术一等奖、四川省青年医学科技奖二等奖等。以第一作者/通讯作者在Biomaterials、Journal of Controlled Release、Chemical Engineering Journal等国内外权威杂志发表高水平学术论文约30篇。

基础研究的主要研究方向如下：①可注射环境响应型水凝胶药物递送系统的研发及应用；②退变椎间盘髓核内基因转运工具的探索与创新；③退变椎间盘髓核基因治疗工具（miRNA、siRNA、基因编辑等）的应用与修复机制研究；④退变椎间盘组织工程修复策略研究；

近3年代表作：

1. Yao D, Li L, Tang Y, Yao J, Liu H, Weng J, et al（Corresponding Author‌）. An ultrasound-driven bioengine for apoptosis inhibition and immune homeostasis regulation in intervertebral disc degeneration. Chemical Engineering Journal. 2026;542.

2. Yao D, Tang Y, Chen H, Yao J, Zhao Z, Liu H, et al（Corresponding Author‌）. A Dual-Strategy Hydrogel Targeting Glycolytic Reprogramming and Inflammation to Inhibit Ferroptosis and Promote Intervertebral Disc Repair. Small. 2026;22(24):e14952.

3. Wang Y, Deng M, Wu Y, Zheng C, Zhang F, Guo C, et al（First Author‌）. A multifunctional mitochondria-protective gene delivery platform promote intervertebral disc regeneration. Biomaterials. 2025;317:123067.

4. Yao D, Yao J, Tang Y, Guo C, Zhang W, Liu H, et al（Corresponding Author‌）. Spatiotemporal hydrogel delivery platform with offense and defense functions for intervertebral disc degeneration: Immune and autophagy modulation. Chemical Engineering Journal. 2025;517:164351.

5. Guo C, Liu Y, Zhao Z, Wu Y, Kong Q, Wang Y. Regulating inflammation and apoptosis: A smart microgel gene delivery system for repairing degenerative nucleus pulposus（Corresponding Author‌）. Journal of Controlled Release. 2024;365:1004-18.9.

6. Guo C, Liu Y, Ma F, Xu X, Zhang W, Zhao Z, et al（Corresponding Author‌）. Microenvironment Remodeling Microgel Repairs Degenerated Intervertebral Disc via Programmed Delivery of MicroRNA-155. ACS Appl Mater Interfaces. 2024;17(4):6009-23.

7. Wang Y, Wu Y, Zhang B, Zheng C, Hu C, Guo C, et al（First Author‌）. Repair of degenerative nucleus pulposus by polyphenol nanosphere-encapsulated hydrogel gene delivery system. Biomaterials. 2023:122132.

8. Wang Y, Zheng C, Wu Y, Zhang B, Hu C, Guo C, et al（First Author‌）. An injectable and self-strengthening nanogel encapsuled hydrogel gene delivery system promotes degenerative nucleus pulposus repair. Composites Part B: Engineering. 2023;250:110469.