主要从事肿瘤靶向与免疫治疗，肿瘤免疫微环境调控机制解析；病原病毒感染致病机制、疫苗设计、迭代优化与临床转化研究。以第一（含共同）身份在Nature、Nature Biomedical Engineering、Nature Communications、Journal of Clinical Investigation、Cellular & Molecular Immunology、Signal Transduction and Targeted Therapy等国际权威期刊发表高水平论文 20 余篇（IF>10），累计总引用量 2000 余次。科研项目方面，作为负责人主持国家自然科学基金青年项目、四川省科技厅面上项目等课题共计 6 项。

1. Yang J, Wang W, Chen Z, Lu S, Yang F, Bi Z, Bao L, et al. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. Nature. 2020. (IF: 48.5，一作)

2. Yang J, Hong W, Lei H, He C, Lei W, Zhou Y, Zhao T, et al. Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection. Signal Transduct Target Ther. 2023 (IF: 52.7，一作)

3. Jingyun Yang, Weiqi Hong, Cai He, Hong Lei, et al. A trivalent self-assembled recombinant protein vaccine confers a broad2 spectrum protective immunity against XBB lineages-included Omicron 3 variants in preclinical and clinal trials. Nat Commun. 2024(IF:15.7，一作)

4. Jingyun Yang, Xuemei He, Cai He, et al. Recombinant XBB.1.5 boosters induce robust neutralization against KP.2-and KP.3-included JN.1 sublineages. Signal Transduct Target Ther. 2022. (IF: 52.7，一作)

5. Jingyun Yang, Weiqi Hong, Cai He, Hong Lei, Hong Yan, et al. A recombinant protein vaccine induces high levels of broad-spectrum neutralizing antibodies against JN.1, BA.2.86 and XBB-lineage subvariants in preclinical and clinal trials. Signal Transduct Target Ther. 2025 (IF: 52.7，一作)

6. He C, Yang J, Hong W, Chen Z, Peng D, Lei H, et al. A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant. Nat Commun. 2022. (IF: 16.6, 共一)

7. Hong W, Cheng P, Yang J, Shi H, et al. Intranasal delivery of combination of adenovirus and trimeric subunit protein induces superior protective immunity in preclinical and clinical trials. Nat Biomed Eng. 2025. (IF:26.7，共一)

8. Lei H, Alu A, Yang J, He X, He C, et al. Cationic crosslinked carbon dots-adjuvanted intranasal vaccine induces protective immunity against Omicron-included SARS-CoV-2 variants. Nat Commun. 2023. (IF: 16.6, 共一)

9. Hong W, Yang J, Zou J, Bi Z, He C, et al. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells. Cell Mol Immunol. 2022. (IF: 24.1, 共一)

10. He C, He X, Yang J, Lei H, et al. Spike protein of SARS-CoV-2 Omicron (B.1.1.529) variant have a reduced ability to induce the immune response. Signal Transduct Target Ther. 2022. (IF: 39.3, 共一)