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长期在陈俐娟教授领衔的团队中聚焦肿瘤、炎症性疾病进行创新药物研发，并与成都赜灵生物医药科技股份有限公司展开紧密合作。主持国家自然科学基金面上项目、青年基金项目、四川省科技厅面上项目、国家博士后基金特别资助项目及其他横向项目。以第一/通讯作者在PNAS，Nat Commun，Sci Adv，J Med Chem，Biomaterials，J Biol Chem，J Adv Res等期刊发表论文20余篇。申请发明专利5项。作为药效部负责人获得国家一类新药临床研究批件一项，目前已进入III期临床。

【代表性论著】

(1)  Yong Li; Chufeng Zhang; Dongmei Tang; Tao Wang; Wei Yan; Linyu Yang; Peng Bai; MinghaiTang; Heying Pei; Lijuan Chen; Qiang Chen; Jianhong Yang ; Identification of a ligand-bindingsite on tubulin mediating the tubulin–RB3 interaction, PNAS（Proceedings of the National Academyof Sciences of the United States of America）, 2025, 122(11): e2424098122。

(2)  Jianhong Yang; Yamei Yu; Yong Li; Wei Yan; Haoyu Ye; Lu Niu; Minghai Tang; Zhoufeng Wang; Zhuang Yang; Heying Pei; Haoche Wei; Min Zhao; Jiaolin Wen; Linyu Yang; Liang Ouyang; Yuquan Wei; Qiang Chen; Weimin Li; Lijuan Chen ; Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect, Science Advances, 2021, 7: eabg4168

(3)  Xueqin Jiang; Xinlu Zhang; Xiaoying Cai; Na Li; Hongyu Zheng; Minghai Tang; Jiangli Zhu; Kaiyue Su; Ruijia Zhang; Neng Ye; Jing Peng; Min Zhao; Wenshuang Wu; Jianhong Yang; Haoyu Ye ; NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation, Science Advances, 2024, 10: eadi9284

(4)  Jianhong Yang; Yong Li; Qiang Qiu; Ruihan Wang; Wei Yan; Yamei Yu; Lu Niu; Heying Pei; Haoche Wei; Liang Ouyang; Haoyu Ye; Dingguo Xu; Yuquan Wei; Qiang Chen; Lijuan Chen ; Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a LowBarrier Hydrogen Bond, Journal of Medicinal Chemistry, 2022, 65: 9159-9173

(5)  Yong Li; Yan Liu; Zhejiang Zhu; Wei Yan; Chufeng Zhang; Zhuang Yang; Peng Bai; Minghai Tang; Mingsong Shi; Wen He; Suhong Fu; Jiang Liu; Kai Han; Jiewen Li; Lixin Xie; Haoyu Ye; Jianhong Yang; Lijuan Chen ; Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents, Journal of Medicinal Chemistry, 2022, 65: 2675-2693。