国家级海外高层次人才引进全职回到四川大学华西医院工作，担任视觉神经生物学及转化医学研究所所长。于2003年获得美国迈阿密大学药理学及神经生物学博士学位，随后于2010年在哈佛大学完成博士后研究，2010-2017年在耶鲁大学任助理教授和副教授。2017-2022年在西奈山伊坎医学院任终身副教授，于2022年晋升为终身正教授并被授予冠名讲席教授。
陈波教授主要从事视网膜退行性疾病的神经生物学机理以及治疗的研究，取得了一系列开创性研究成果。以最后通讯作者身份发表论文在国际知名期刊上，包括 “Cell”, “Nature”, “Science”, “Nature Communications”, “eBioMedicine”, “eLife”, “Molecular Therapy”和 “Cell Reports”。研究工作和成果多次被最高学术刊物和主流媒体报道并给予了高度评价，包括 Science Magazine，Nature Reviews Neuroscience，Nature Medicine，U.S. News & World Report，新华社、新华网、人民网、新浪网等等。
Module director: NIH-funded P30 Vision Core Grant at Yale (2012-2017)
Director: The Ocular Stem Cell Program at Icahn School of Medicine at Mount Sinai (2017-2025)
1. Zhou J, Wan Y, Anderson MG, Duh EJ, Demb JB, Guo X†, Chen B†.
“CaMKII-based gene therapy protects retinal ganglion cells in a broad range of disease:
ischemic retinopathy and congenital glaucoma”.
Molecular Therapy. 2026 May 6;34(5):2770-2780. doi: 10.1016/j.ymthe.2026.01.036.
Research Highlights: “Toward a universal neuroprotective strategy for vision preservation”
Molecular Therapy. 2026 May 6;34(5):2541-2543. doi: 10.1016/j.ymthe.2026.02.038.
2. Xie Y, Zhou J, Wang LL, Zhang CL, Chen B†.
“New AAV tools fail to detect Neurod1-mediated neuronal conversion of Müller glia and
astrocytes in vivo”.
eBioMedicine. 2023 Mar 20;90:104531. doi: 10.1016/j.ebiom.2023.104531.
3. Xie Y, Zhou J, Chen B†.
“Critical examination of Ptbp1-mediated glia-to-neuron conversion in the mouse retina ”.
Cell Reports.2022 Jun 14;39(11):110960. doi: 10.1016/j.celrep.2022.110960.
4. Guo XZ, Zhou J, Starr C, Mohns EJ, Li YD, Chen E, Yoon YJ, Kellner C, Tanaka K, Wang HB, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B†.
“Preservation of vision after CaMKII-mediated protection of retinal ganglion cells”.
Cell. 2021 Jul 14;S0092-8674(21)00799-6. doi: 10.1016/j.cell.2021.06.031.
Research Highlights: “Retinal protection”.
Nature Reviews Neuroscience. 2021; https://doi.org/10.1038/s41583-021-00512-1.
5. Yao K, Qiu S, Wang Y, Park S, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B†.
“Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas.”
Nature. 2018 Aug;560(7719):484-488.
Research Highlights: “Restoring sight with native cell reprogramming”.
Nature Medicine 24, 1303 (2018). https://doi.org/10.1038/s41591-018-0192-6.
6. Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B†.
“Wnt regulates proliferation and neurogenic potential of Müller glial cells through a Lin28/let-7 miRNA-dependent pathway in adult mammalian retina”.
Cell Reports. 2016 Sep 27;17(1):165-78.
7. Guo XZ, Snider WD, Chen B†. “GSK3β regulates AKT-induced CNS axon regeneration through an eIF2Bε-dependent, mTOR-independent signaling pathway”.
eLife. 2016;5:e11903.
Research Highlights: “Enzymes help to regrow nerves”.
Nature. 2016 April 7:v532.
8. Guo XZ, Wang SB, Xu HP, Ribic A, Mohns EJ, Zhou Y, Zhu XJ, Biederer T, Crair MC, Chen B†.
“A Short N-terminal Domain of HDAC4 Preserves Photoreceptors and Restores Visual Function in Retinitis Pigmentosa”.
Nature Communications. 2015 Aug 14;6:8005. doi:10.1038/ncomms9005.
9. Chen B and Cepko CL.
“HDAC4 regulates neuronal survival in normal and diseased retinas”.
Science. 2009 Jan 9;323(5911):256-9. PMID 19131628.
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